Loading...
Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression.
Parhi, Lishay Alon-Maimon, Tamar Sol, Asaf Nejman, Deborah Shhadeh, Amjad Fainsod-Levi, Tanya Yajuk, Olga Isaacson, Batya Abed, Jawad Maalouf, Naseem
Parhi, Lishay
Alon-Maimon, Tamar
Sol, Asaf
Nejman, Deborah
Shhadeh, Amjad
Fainsod-Levi, Tanya
Yajuk, Olga
Isaacson, Batya
Abed, Jawad
Maalouf, Naseem
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2020-06-26
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 2.25 MB
Other Titles
Abstract
Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice, hematogenous F. nucleatum can colonize CRC tissue using its lectin Fap2, which attaches to tumor-displayed Gal-GalNAc. Here, we show that Gal-GalNAc levels increase as human breast cancer progresses, and that occurrence of F. nucleatum gDNA in breast cancer samples correlates with high Gal-GalNAc levels. We demonstrate Fap2-dependent binding of the bacterium to breast cancer samples, which is inhibited by GalNAc. Intravascularly inoculated Fap2-expressing F. nucleatum ATCC 23726 specifically colonize mice mammary tumors, whereas Fap2-deficient bacteria are impaired in tumor colonization. Inoculation with F. nucleatum suppresses accumulation of tumor infiltrating T cells and promotes tumor growth and metastatic progression, the latter two of which can be counteracted by antibiotic treatment. Thus, targeting F. nucleatum or Fap2 might be beneficial during treatment of breast cancer.
Citation
Nat Commun. 2020;11(1):3259. Published 2020 Jun 26. doi:10.1038/s41467-020-16967-2.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
2041-1723
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International