Loading...
Kenalactams A-E, Polyene Macrolactams Isolated from Nocardiopsis CG3.
Messaoudi, Omar Sudarman, Enge Bendahou, Mourad Jansen, Rolf Wink, Joachim
Messaoudi, Omar
Sudarman, Enge
Bendahou, Mourad
Jansen, Rolf
Wink, Joachim
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2019-05-24
Submitted date
Files
Loading...
original manuscript
Adobe PDF, 1.4 MB
Other Titles
Abstract
In our screening program for new biologically active secondary metabolites, a new strain, Nocardiopsis CG3 (DSM 106572), isolated from the saltpan of Kenadsa, was found to produce five new polyene macrolactams, the kenalactams A-E (1-5). Their structures were elucidated by spectral methods (NMR and HRESIMS), and the absolute configuration was derived by chemical derivatization (Mosher's method). Through a feeding experiment, alanine was proven to be the nitrogen-bearing starter unit involved in biosynthesis of the polyketide kenalactam A (1). Kenalactam E (5) was cytotoxic against human prostate cancer PC-3 cells with an IC50 value of 2.1 μM.
Citation
Nat Prod. 2019 May 24;82(5):1081-1088. doi: 10.1021/acs.jnatprod.8b00708. Epub 2019 Apr 25.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1520-6025
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International