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[Occurrence of bronchial asthma and age at initial asthma diagnosis-first results of the German National Cohort].
Langer, Susan Horn, Johannes Kluttig, Alexander Mikolajczyk, Rafael Karrasch, Stefan Schulz, Holger Wichmann, Heinz-Erich Linseisen, Jakob Jaeschke, Lina Pischon, Tobias
Langer, Susan
Horn, Johannes
Kluttig, Alexander
Mikolajczyk, Rafael
Karrasch, Stefan
Schulz, Holger
Wichmann, Heinz-Erich
Linseisen, Jakob
Jaeschke, Lina
Pischon, Tobias
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2020-03-03
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Abstract
BACKGROUND: Asthma is one of the most common chronic diseases in both children and adults. Asthma first occurring in adulthood (adult-onset asthma, AOA) is associated with poorer prognosis compared to childhood-onset asthma (COA), which urgently calls for more research in this area. The aim of this work was to analyze the data on asthma collected in the German National Cohort and compare it with the German Health Interview and Examination Survey for Adults (DEGS), in particular regarding AOA. MATERIAL AND METHODS: Our analysis was based on the dataset of the main questionnaire at mid-term of the German National Cohort baseline examination, comprising 101,723 participants. Variables considered in the analyses were self-reported diagnosis of asthma, age at first diagnosis, asthma treatment in the past 12 months, age, and sex. RESULTS: In the midterm dataset, 8.7% of women and 7.0% of men in the German National Cohort reported that they had ever been diagnosed with asthma. Approximately one third of participants with asthma received their initial diagnosis before their 18th birthday. COA affected 2.2% of women and 2.8% of men, whereas AOA affected 6.5% of women and 4.2% of men. During the previous 12 months, 33% of COA cases and 60% of AOA cases were medically treated. CONCLUSION: The proportion of persons affected by asthma in the German National Cohort, as well as observed patterns regarding age and gender, corresponds to other data sources such as DEGS. However, in our analysis, the proportion of individuals with AOA was higher than described in the literature. The increase in cumulative asthma diagnoses with age is markedly steeper in younger participants, indicating a rising trend over time.
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Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020 Mar 3. pii: 10.1007/s00103-020-03105-y. doi: 10.1007/s00103-020-03105-y.
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de
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1437-1588
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Attribution-NonCommercial-ShareAlike 4.0 International