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Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia.

Karch, André
; 
Manthey, Henrike
; 
Ponto, Claudia
; 
Hermann, Peter
; 
Heinemann, Uta
; 
Schmidt, Christian
; 
Zerr, Inga
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2013
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Abstract
Since more than a decade ApoE is known to be a strong risk factor for Alzheimer's disease (AD); however, molecular pathways mediating this risk are still unclear. In recent years it has been hypothesized that ApoE might play a role in the disintegration of blood-brain barrier (BBB). In the present study we addressed the question if ApoE genotypes might be associated with BBB function measured by albumin ratio (QAlb) in a large cohort of patients with different types of dementia.
Citation
Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia. 2013, 8 (12):e84405 PLoS ONE
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PloS one
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http://hdl.handle.net/10033/311617
DOI
10.1371/journal.pone.0084405
PubMed ID
24386372
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en
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1932-6203
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publications of the research group of epidemiology (EPID)