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High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse.
Velázquez-Avila, Martha Balandrán, Juan Carlos Ramírez-Ramírez, Dalia Velázquez-Avila, Mirella Sandoval, Antonio Felipe-López, Alfonso Nava, Porfirio Alvarado-Moreno, José Antonio Dozal, David Prieto-Chávez, Jessica L
Velázquez-Avila, Martha
Balandrán, Juan Carlos
Ramírez-Ramírez, Dalia
Velázquez-Avila, Mirella
Sandoval, Antonio
Felipe-López, Alfonso
Nava, Porfirio
Alvarado-Moreno, José Antonio
Dozal, David
Prieto-Chávez, Jessica L
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2018-12-20
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Abstract
Cancer is a major cause of death in children worldwide, with B-lineage cell acute lymphoblastic leukemia (B-ALL) being the most frequent childhood malignancy. Relapse, treatment failure and organ infiltration worsen the prognosis, warranting a better understanding of the implicated mechanisms. Cortactin is an actin-binding protein involved in cell adhesion and migration that is overexpressed in many solid tumors and in adult B-cell chronic lymphocytic leukemia. Here, we investigated cortactin expression and potential impact on infiltration and disease prognosis in childhood B-ALL. B-ALL cell lines and precursor cells from bone marrow (BM) and cerebrospinal fluid (CSF) of B-ALL patients indeed overexpressed cortactin. In CXCL12-induced transendothelial migration assays, transmigrated B-ALL cells had highest cortactin expression. In xenotransplantation models, only cortactin
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en
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1476-5551
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Attribution-NonCommercial-ShareAlike 4.0 International