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New RNA-seq approaches for the study of bacterial pathogens.
Saliba, Antoine-Emmanuel C Santos, Sara
Saliba, Antoine-Emmanuel
C Santos, Sara
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2017-01-01
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Understanding how bacteria cause disease requires knowledge of which genes are expressed and how they are regulated during infection. While RNA-seq is now a routine method for gene expression analysis in bacterial pathogens, the past years have also witnessed a surge of novel RNA-seq based approaches going beyond standard mRNA profiling. These include variations of the technique to capture post-transcriptional networks controlled by small RNAs and to discover associated RNA-binding proteins in the pathogen itself. Dual RNA-seq analyzing pathogen and host simultaneously has revealed roles of noncoding RNAs during infection and enabled the correlation of bacterial gene activity with specific host responses. Single-cell RNA-seq studies have addressed how heterogeneity among individual host cells may determine infection outcomes.
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1879-0364
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Attribution-NonCommercial-ShareAlike 3.0 United States