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Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand, Nicolas
Ploss, Alexander
Balling, Rudi
Becker, Pablo D
Borsotti, Chiara
Brezillon, Nicolas
Debarry, Jennifer
de Jong, Ype
Deng, Hongkui
Di Santo, James P
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2009-07-23
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Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
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Humanized mice for modeling human infectious disease: challenges, progress, and outlook. 2009, 6 (1):5-9 Cell Host Microbe
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en
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1934-6069
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