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In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome.

Todt, Daniel
; 
Gisa, Anett
; 
Radonic, Aleksandar
; 
Nitsche, Andreas
; 
Behrendt, Patrick
; 
Suneetha, Pothakamuri Venkata
; 
Pischke, Sven
; 
Bremer, Birgit
; 
Brown, Richard J P
; 
Manns, Michael P
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2016-10
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Abstract
Hepatitis E virus (HEV) infection can take chronic courses in immunocompromised patients potentially leading to liver cirrhosis and liver failure. Ribavirin (RBV) is currently the only treatment option for many patients, but treatment failure can occur which has been associated with the appearance of a distinct HEV polymerase mutant (G1634R). Here, we performed a detailed analysis of HEV viral intrahost evolution during chronic hepatitis E infections.
Citation
In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. 2016, 65 (10):1733-43 Gut
Affiliation
Twincore Centre of Experimental and Clinical Infection Research; a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover 30625, Germany.
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Journal
Gut
URI
http://hdl.handle.net/10033/620804
DOI
10.1136/gutjnl-2015-311000
PubMed ID
27222534
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Article
Language
en
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1468-3288
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publications of the research group virus transmission ([TC]VIRT)