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Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology.

Nazir, Mamona
; 
Saleem, Muhammad
; 
Tousif, Muhammad Imran
; 
Anwar, Muhammad Aijaz
; ; 
Ali, Iftikhar
; 
Wang, Daijie
; 
Mamadalieva, Nilufar Z
; 
Alshammari, Elham
; 
Ashour, Mohamed L
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Issue Date
2021-06-29
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Abstract
Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.
Citation
Biomolecules. 2021 Jun 29;11(7):957. doi: 10.3390/biom11070957.
Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
Publisher
MDPI
Journal
Biomolecules
URI
http://hdl.handle.net/10033/622969
DOI
10.3390/biom11070957
PubMed ID
34209734
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Type
Review
Language
en
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2218-273X
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Attribution 4.0 International
cb
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publications of the research group of microbial drugs (MWIS)