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Growth-uncoupled isoprenoid synthesis in Rhodobacter sphaeroides.
Orsi, Enrico Mougiakos, Ioannis Post, Wilbert Beekwilder, Jules Dompè, Marco Eggink, Gerrit van der Oost, John Kengen, Servé W M Weusthuis, Ruud A
Orsi, Enrico
Mougiakos, Ioannis
Post, Wilbert
Beekwilder, Jules
Dompè, Marco
Eggink, Gerrit
van der Oost, John
Kengen, Servé W M
Weusthuis, Ruud A
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2020-07-13
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Abstract
Microbial cell factories are usually engineered and employed for cultivations that combine product synthesis with growth. Such a strategy inevitably invests part of the substrate pool towards the generation of biomass and cellular maintenance. Hence, engineering strains for the formation of a specific product under non-growth conditions would allow to reach higher product yields. In this respect, isoprenoid biosynthesis represents an extensively studied example of growth-coupled synthesis with rather unexplored potential for growth-independent production. Rhodobacter sphaeroides is a model bacterium for isoprenoid biosynthesis, either via the native 2-methyl-d-erythritol 4-phosphate (MEP) pathway or the heterologous mevalonate (MVA) pathway, and for poly-β-hydroxybutyrate (PHB) biosynthesis.
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Biotechnol Biofuels. 2020 Jul 13;13:123. doi: 10.1186/s13068-020-01765-1.
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en
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1754-6834