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Hemodialysis-related changes in phenotypical features of monocytes.

Liakopoulos, Vassilios
; 
Jeron, Andreas
; 
Shah, Aneri
; ; 
Mertens, Peter R
; 
Gorny, Xenia
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2018-09-18
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Abstract
Hemodialysis (HD) patients exhibit chronic inflammation and leukocyte activation. We investigated the surface-marker profile of monocytes by flow cytometry to assess the chronic effect of uremia and the acute effect of dialysis on their phenotypical and functional features in 16 healthy controls (CON) and 15 HD patients before and after a polysulfone-based dialysis session. Median fluorescence intensities were analyzed indicating expression of CD14, CD16, integrins (CD11b, CD18), chemokine receptors (CCR2, CX3CR1), scavenger receptors (CD36, CD163) and Toll-like receptor-2 (TLR2). Before and after dialysis, HD patients harbour 0.9-fold less CD14
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Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
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http://hdl.handle.net/10033/621558
DOI
10.1038/s41598-018-31889-2
PubMed ID
30228352
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Article
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2045-2322
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Attribution-NonCommercial-ShareAlike 3.0 United States
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publications of the work group immunoregulation (IREG)