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Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy.

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Berk, L
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2019-05-30
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Abstract
Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity. Therefore, a model with heterogeneity was developed and tested using existing experimental data to show the potential effects from the presence of an intratumoral distribution of radiosensitivity on radiation therapy response over a protracted radiation therapy treatment course.
Citation
Radiat Oncol. 2019 May 30;14(1):88. doi: 10.1186/s13014-019-1288-y.
Affiliation
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.
Publisher
BioMed Central (BMC)
Journal
Radiation Oncology
URI
http://hdl.handle.net/10033/621830
DOI
10.1186/s13014-019-1288-y
PubMed ID
31146751
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Article
Language
en
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ISSN
1748-717X
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Attribution-NonCommercial-ShareAlike 4.0 International
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publications of the research group system immunology ([BRICS]SIMM)