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New Deoxyenhygrolides from Provide Insights into Butenolide Core Biosynthesis.
Hug, Joachim J Kjaerulff, Louise Garcia, Ronald Müller, Rolf
Hug, Joachim J
Kjaerulff, Louise
Garcia, Ronald
Müller, Rolf
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2022-01-14
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Abstract
Marine myxobacteria present a virtually unexploited reservoir for the discovery of natural products with diverse biological functions and novel chemical scaffolds. We report here the isolation and structure elucidation of eight new deoxyenhygrolides (1-8) from the marine myxobacterium Plesiocystis pacifica DSM 14875T. The herein described deoxyenhygrolides C-J (1-8) feature a butenolide core with an ethyl residue at C-3 of the γ-lactone in contrast to the previously described derivatives, deoxyenhygrolides A and B, which feature an isobutyl residue at this position. The butenolide core is 2,4-substituted with a benzyl (1, 2 and 7), benzoyl (3 and 4) or benzyl alcohol (5, 6 and 8) moiety in the 2-position and a benzylidene (1-6) or benzylic hemiketal (7 and 8) in the 4-position. The description of these new deoxyenhygrolide derivatives, alongside genomic in silico investigation regarding putative biosynthetic genes, provides some new puzzle pieces on how this natural product class might be formed by marine myxobacteria.
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Mar Drugs. 2022 Jan 14;20(1):72. doi: 10.3390/md20010072.
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en
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1660-3397
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Attribution 4.0 International