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Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
Montefusco-Pereira, Carlos V. Formicola, Beatrice Goes, Adriely Re, Francesca Marrano, Claudia A. Mantegazza, Francesco Carvalho-Wodarz, Cristiane Caneva, Enrico Nicotra, Francesco
Montefusco-Pereira, Carlos V.
Formicola, Beatrice
Goes, Adriely
Re, Francesca
Marrano, Claudia A.
Mantegazza, Francesco
Carvalho-Wodarz, Cristiane
Caneva, Enrico
Nicotra, Francesco
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2020-04
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By functionalizing the surface of PEG-liposomes with linkers bearing quaternary ammonium compounds (QACs), we generated novel bacteria disruptors with anti-adhesive properties and reduced cytotoxicity compared to free QACs. Furthermore, QAC-functionalized liposomes are a promising platform for future drug encapsulation. The QAC (11-mercaptoundecyl)-N,N,N-trimethylammonium bromide (MTAB) was attached to maleimide-functionalized liposomes (DSPE-PEG) via thiol linker. The MTAB-functionalized liposomes were physicochemically characterized and their biological activity, in terms of anti-adherence activity and biofilm prevention in Escherichia coli were assessed. The results showed that MTAB-functionalized liposomes inhibit bacterial adherence and biofilm formation while reducing MTAB toxicity.
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Eur J Pharm Biopharm. 2020 Jan 30. pii: S0939-6411(20)30024-2. doi:10.1016/j.ejpb.2020.01.013.
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0939-6411
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Attribution-NonCommercial-ShareAlike 4.0 International