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Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.

Koutsoudakis, George
; 
Romero-Brey, Inés
; 
Berger, Carola
; 
Pérez-Vilaró, Gemma
; 
Monteiro Perin, Paula
; 
Vondran, Florian Wolfgang Rudolf
; 
Kalesse, Markus
; 
Harmrolfs, Kirsten
; ; 
Martinez, Javier P
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2015-06-10
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Abstract
Soraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human immunodeficiency virus (HIV). The aim of the present study was to evaluate the capacity of SorA and analogues to inhibit hepatitis C virus (HCV) infection.
Citation
Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. 2015: J. Hepatol.
Affiliation
TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen Str. 7, 30625, Hannover, Germany.
Publisher
Journal
Journal of hepatology
URI
http://hdl.handle.net/10033/577529
DOI
10.1016/j.jhep.2015.06.002
PubMed ID
26070407
PubMed Central ID
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1600-0641
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Publications of the research group Chemical Biology (CBIO)