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Kinome analysis of receptor-induced phosphorylation in human natural killer cells.

König, Sebastian
; 
Nimtz, Manfred
; 
Scheiter, Maxi
; 
Ljunggren, Hans-Gustaf
; 
Bryceson, Yenan T
; 
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2012
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Abstract
Natural killer (NK) cells contribute to the defense against infected and transformed cells through the engagement of multiple germline-encoded activation receptors. Stimulation of the Fc receptor CD16 alone is sufficient for NK cell activation, whereas other receptors, such as 2B4 (CD244) and DNAM-1 (CD226), act synergistically. After receptor engagement, protein kinases play a major role in signaling networks controlling NK cell effector functions. However, it has not been characterized systematically which of all kinases encoded by the human genome (kinome) are involved in NK cell activation.
Citation
Kinome analysis of receptor-induced phosphorylation in human natural killer cells. 2012, 7 (1):e29672 PLoS ONE
Affiliation
Department of Molecular Structural Biology, Helmholtz-Zentrum für Infektionsforschung, Braunschweig, Germany.
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PloS one
URI
http://hdl.handle.net/10033/227676
DOI
10.1371/journal.pone.0029672
PubMed ID
22238634
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Article
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en
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1932-6203
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Publications from Division of Molekulare Struktur Biologie (MOSB)