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Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs.
Siddharta, Anindya Pfaender, Stephanie Malassa, Angelina Doerrbecker, Juliane Anggakusuma Engelmann, Michael Nugraha, Boya Steinmann, Joerg Todt, Daniel Vondran, Florian W R
Siddharta, Anindya
Pfaender, Stephanie
Malassa, Angelina
Doerrbecker, Juliane
Anggakusuma
Engelmann, Michael
Nugraha, Boya
Steinmann, Joerg
Todt, Daniel
Vondran, Florian W R
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Issue Date
2016-11-18
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Abstract
Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.
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Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. 2016, 6:36619 Sci Rep
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en
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2045-2322