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Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a cross-sectional study.
Wells, Philippa M Adebayo, Adewale S Bowyer, Ruth C E Freidin, Maxim B Finckh, Axel Strowig, Till Lesker, Till Robin Alpizar-Rodriguez, Deshire Gilbert, Benoit Kirkham, Bruce
Wells, Philippa M
Adebayo, Adewale S
Bowyer, Ruth C E
Freidin, Maxim B
Finckh, Axel
Strowig, Till
Lesker, Till Robin
Alpizar-Rodriguez, Deshire
Gilbert, Benoit
Kirkham, Bruce
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2020-06-25
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WellsStrowig.pdf
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We found that presence of Prevotella spp were positively associated with the rheumatoid arthritis PRS in TwinsUK participants (q<1 × 10-7). This finding was validated in SCREEN-RA participants (n=133) carrying established shared epitope risk alleles (q=0·0011). We also found an association between Prevotella spp and presence of preclinical rheumatoid arthritis phases (q=0·021).
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en
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2665-9913
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Attribution 4.0 International