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A Single-Center Prospective Cohort Study on Postsplenectomy Sepsis and its Prevention.
Rieg, Siegbert Bechet, Lena Naujoks, Kai Hromek, Julia Lange, Berit Juzek-Küpper, Marc-Fabian Stete, Katarina Müller, Matthias C Jost, Insa Kern, Winfried V
Rieg, Siegbert
Bechet, Lena
Naujoks, Kai
Hromek, Julia
Lange, Berit
Juzek-Küpper, Marc-Fabian
Stete, Katarina
Müller, Matthias C
Jost, Insa
Kern, Winfried V
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2020-02-13
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Abstract
A total of 459 asplenic patients were enrolled, and 426 patients were followed prospectively over a median period of 2.9 years. Pneumococcal vaccine uptake within 3 months of splenectomy or first diagnosis of asplenia was 27% vs 71% among delayed study entry and early study entry patients, respectively (P < .001). Forty-four episodes of severe sepsis or septic shock occurred in study patients: 22 after study entry and 22 before study entry. Streptococcus pneumoniae was more frequent among sepsis episodes that occurred before study entry (8/22) than after study entry (1/22 episodes). For episodes occurring after study entry, only a higher Charlson comorbidity index score was significantly associated with severe sepsis/septic shock postsplenectomy.
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Open Forum Infect Dis. 2020;7(3):ofaa050. Published 2020 Feb 13. doi:10.1093/ofid/ofaa050.
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Article
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en
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2328-8957
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Attribution-NonCommercial-ShareAlike 4.0 International