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Listeria monocytogenes induces T cell receptor unresponsiveness through pore-forming toxin listeriolysin O.

Gekara, Nelson O
; 
Zietara, Natalia
; ; 
Weiss, Siegfried
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2010-12-01
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Abstract
The success of many pathogens relies on their ability to circumvent the innate and adaptive immune defenses. How bacterial pathogens subvert adaptive immune defenses is not clear. Cholesterol-dependent cytolysins (CDCs) represent an expansive family of homologous pore-forming toxins that are produced by more than 20 gram-positive bacterial species. Listeriolysin O (LLO), a prototype CDC, is the main virulence factor of Listeria monocytogenes.
Citation
Listeria monocytogenes induces T cell receptor unresponsiveness through pore-forming toxin listeriolysin O. 2010, 202 (11):1698-707 J. Infect. Dis.
Affiliation
Molecular Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany. nelson.gekara@mims.umu.se
Publisher
Journal
The Journal of infectious diseases
URI
http://hdl.handle.net/10033/126271
DOI
10.1086/657145
PubMed ID
20961225
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Article
Language
en
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1537-6613
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publications of the research group molecular Immunology (MOLI)