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Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.
Strobel, Tina Schmidt, Yvonne Linnenbrink, Anton Luzhetska, Marta Taguchi, Takaaki Brötz, Elke Paululat, Thomas Stasevych, Maryna Stanko, Oleg
Strobel, Tina
Schmidt, Yvonne
Linnenbrink, Anton
Luzhetska, Marta
Taguchi, Takaaki
Brötz, Elke
Paululat, Thomas
Stasevych, Maryna
Stanko, Oleg
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2013-09
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Abstract
Saccharothrix espanaensis is a member of the order Actinomycetales. The genome of the strain has been sequenced recently, revealing 106 glycosyltransferase genes. In this paper, we report the detection of a glycosyltransferase from Saccharothrix espanaensis which is able to rhamnosylate different phenolic compounds targeting different positions of the molecules. The gene encoding the flexible glycosyltransferase is not located close to a natural product biosynthetic gene cluster. Therefore, the native function of this enzyme might be not the biosynthesis of a secondary metabolite but the glycosylation of internal and external natural products as part of a defense mechanism.
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Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. 2013, 79 (17):5224-32 Appl. Environ. Microbiol.
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en
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1098-5336
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Archived with thanks to Applied and environmental microbiology