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Total synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block.
Galeyeva, Yana Helbig, Sarah Morr, Michael Sasse, Florenz Nimtz, Manfred Laschat, Sabine Baro, Angelika
Galeyeva, Yana
Helbig, Sarah
Morr, Michael
Sasse, Florenz
Nimtz, Manfred
Laschat, Sabine
Baro, Angelika
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2006-08
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Abstract
Unnatural (-)-pectinatone ((-)-3) was prepared in five steps starting from the highly methyl-branched wax ester 4, employing bromination of the ester enolate and subsequent base-induced elimination to the enoate 6 as the key step. Both (-)-3 and the amides 8b and 8c, which were isolated as by-products in the reaction sequence, displayed antimicrobial activity and cytotoxicity.
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Total synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block. 2006, 3 (8):935-41 Chem. Biodivers.
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en
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1612-1880