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HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
Raza, Syed Ahsan Albrecht, Anne Çalışkan, Gürsel Müller, Bettina Demiray, Yunus Emre Ludewig, Susann Meis, Susanne Faber, Nicolai Hartig, Roland Schraven, Burkhart
Raza, Syed Ahsan
Albrecht, Anne
Çalışkan, Gürsel
Müller, Bettina
Demiray, Yunus Emre
Ludewig, Susann
Meis, Susanne
Faber, Nicolai
Hartig, Roland
Schraven, Burkhart
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2017-08-04
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Abstract
Cholinergic neuromodulation in the hippocampus controls the salience of background context memory acquired in the presence of elemental stimuli predicting an aversive reinforcement. With pharmacogenetic inhibition we here demonstrate that hilar perforant path-associated (HIPP) cells of the dentate gyrus mediate the devaluation of background context memory during Pavlovian fear conditioning. The salience adjustment is sensitive to reduction of hilar neuropeptide Y (NPY) expression via dominant negative CREB expression in HIPP cells and to acute blockage of NPY-Y1 receptors in the dentate gyrus during conditioning. We show that NPY transmission and HIPP cell activity contribute to inhibitory effects of acetylcholine in the dentate gyrus and that M1 muscarinic receptors mediate the cholinergic activation of HIPP cells as well as their control of background context salience. Our data provide evidence for a peptidergic local circuit in the dentate gyrus that mediates the cholinergic encoding of background context salience during fear memory acquisition.Intra-hippocampal circuits are essential for associating a background context with behaviorally salient stimuli and involve cholinergic modulation at SST(+) interneurons. Here the authors show that the salience of the background context memory is modulated through muscarinic activation of NPY(+) hilar perforant path associated interneurons and NPY signaling in the dentate gyrus.
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HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. 2017, 8 (1):189 Nat Commun
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en
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2041-1723