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Synthesis and aromatase inhibitory activity of some new 16E-arylidenosteroids.
Bansal, Ranju Thota, Sridhar Karkra, Nalin Minu, Maninder Zimmer, Christina Hartmann, Rolf W
Bansal, Ranju
Thota, Sridhar
Karkra, Nalin
Minu, Maninder
Zimmer, Christina
Hartmann, Rolf W
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2012-12
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Abstract
A new series of 16E-arylidene androstene derivatives has been synthesized and evaluated for aromatase inhibitory activity. The impact of various aryl substituents at 16 position of the steroid skeleton on aromatase inhibitory activity has been observed. The 16E-arylidenosteroids 6, 10 and 11 exhibited significant inhibition of the aromatase enzyme. 16-(4-Pyridylmethylene)-4-androstene-3,17-dione (6, IC(50): 5.2 μM) and 16-(benzo-[1,3]dioxol-5-ylmethylene)androsta-1,4-diene-3,17-dione (11, IC(50): 6.4 μM) were found to be approximately five times more potent in comparison to aminoglutethimide.
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Synthesis and aromatase inhibitory activity of some new 16E-arylidenosteroids. 2012, 45:36-40 Bioorg. Chem.
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en
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1090-2120
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Archived with thanks to Bioorganic chemistry