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Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.
Torow, Natalia Yu, Kai Hassani, Kasra Freitag, Jenny Schulz, Olga Basic, Marijana Brennecke, Anne Sparwasser, Tim Wagner, Norbert Bleich, André
Torow, Natalia
Yu, Kai
Hassani, Kasra
Freitag, Jenny
Schulz, Olga
Basic, Marijana
Brennecke, Anne
Sparwasser, Tim
Wagner, Norbert
Bleich, André
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Abstract
Priming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the small intestine and quickly acquire a distinct transcriptional profile. T-cell recruitment is independent of microbial colonization and innate or adaptive immune stimulation but requires β7 integrin expression. Surprisingly, neonatal CD4 T cells remain immature throughout the postnatal period under homeostatic conditions but undergo maturation and gain effector function on barrier disruption. Maternal SIgA and regulatory T cells act in concert to prevent immune stimulation and maintain the immature phenotype of CD4 T cells in the postnatal intestine during homeostasis. Active suppression of CD4 T-cell maturation during the postnatal period might contribute to prevent auto-reactivity, sustain a broad TCR repertoire and establish life-long immune homeostasis.
Citation
Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period. 2015, 6:7725 Nat Commun
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Journal
PubMed ID
PubMed Central ID
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Article
Language
en
Description
Series/Report no.
ISSN
2041-1723