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Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy.
Bošnjak, Berislav Odak, Ivan Ritter, Christiane Stahl, Klaus Graalmann, Theresa Steinbrück, Lars Blasczyk, Rainer Falk, Christine S Schulz, Thomas F Wedemeyer, Hans Heinrich
Bošnjak, Berislav
Odak, Ivan
Ritter, Christiane
Stahl, Klaus
Graalmann, Theresa
Steinbrück, Lars
Blasczyk, Rainer
Falk, Christine S
Schulz, Thomas F
Wedemeyer, Hans Heinrich
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2021-08-12
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Abstract
Here, we described the case of a B cell-deficient patient after CD19 CAR-T cell therapy for refractory B cell Non-Hodgkin Lymphoma with protracted coronavirus disease 2019 (COVID-19). For weeks, this patient only inefficiently contained the virus while convalescent plasma transfusion correlated with virus clearance. Interestingly, following convalescent plasma therapy natural killer cells matured and virus-specific T cells expanded, presumably allowing virus clearance and recovery from the disease. Our findings, thus, suggest that convalescent plasma therapy can activate cellular immune responses to clear SARS-CoV-2 infections. If confirmed in larger clinical studies, these data could be of general importance for the treatment of COVID-19 patients.
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Front Immunol. 2021 Aug 12;12:721738. doi: 10.3389/fimmu.2021.721738.
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en
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1664-3224
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Attribution 4.0 International