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Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.
Lüdtke, Anja Ruibal, Paula Becker-Ziaja, Beate Rottstegge, Monika Wozniak, David M Cabeza-Cabrerizo, Mar Thorenz, Anja Weller, Romy Kerber, Romy Idoyaga, Juliana
Lüdtke, Anja
Ruibal, Paula
Becker-Ziaja, Beate
Rottstegge, Monika
Wozniak, David M
Cabeza-Cabrerizo, Mar
Thorenz, Anja
Weller, Romy
Kerber, Romy
Idoyaga, Juliana
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2016-10-15
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A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16(+) monocytes with a poor activation profile. In survivors, CD16(+) monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology.
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Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes. 2016, 214 (suppl 3):S275-S280 J. Infect. Dis.
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1537-6613
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openAccess