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The Total Synthesis of Chondrochloren A.
Linne, Yannick Bonandi, Elisa Tabet, Christopher Geldsetzer, Jan Kalesse, Markus
Linne, Yannick
Bonandi, Elisa
Tabet, Christopher
Geldsetzer, Jan
Kalesse, Markus
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2021-02-25
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Abstract
The first total synthesis of chondrochloren A is accomplished using a 1,2-metallate rearrangement addition as an alternative for the Nozaki-Hiyama-Kishi reaction. This transformation also avoids the inherent challenges of this polyketide segment and provides a new, unprecedented strategy to assemble polyketidal frameworks. The formation of the Z-enamide is accomplished using a Z-selective cross coupling of the corresponding amide to a Z-vinyl bromide.
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Angew Chem Int Ed Engl. 2021 Mar 22;60(13):6938-6942. doi: 10.1002/anie.202016072. Epub 2021 Feb 25.
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Article
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en
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1521-3773
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Attribution 4.0 International