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The structural biology of phenazine biosynthesis.

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Parsons, James F
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2014-09-09
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Abstract
The phenazines are a class of over 150 nitrogen-containing aromatic compounds of bacterial and archeal origin. Their redox properties not only explain their activity as broad-specificity antibiotics and virulence factors but also enable them to function as respiratory pigments, thus extending their importance to the primary metabolism of phenazine-producing species. Despite their discovery in the mid-19th century, the molecular mechanisms behind their biosynthesis have only been unraveled in the last decade. Here, we review the contribution of structural biology that has led to our current understanding of phenazine biosynthesis.
Citation
The structural biology of phenazine biosynthesis. 2014, 29C:26-33 Curr. Opin. Struct. Biol.
Affiliation
Helmholtz Centre for Infection Research, Structure and Function of Proteins, Inhoffenstr. 7, 38124 Braunschweig, Germany. Electronic address: wulf.blankenfeldt@helmholtz-hzi.de.
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Journal
Current opinion in structural biology
URI
http://hdl.handle.net/10033/337028
DOI
10.1016/j.sbi.2014.08.013
PubMed ID
25215885
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1879-033X
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Publications of the research group structure and functions of Proteins(SFPR)