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Biochemistry of proinflammatory macrophage activation.
Nonnenmacher, Yannic Hiller, Karsten
Nonnenmacher, Yannic
Hiller, Karsten
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2018-03-03
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Abstract
In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.
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Biochemistry of proinflammatory macrophage activation. 2018 Cell. Mol. Life Sci.
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Article
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en
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1420-9071