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Computer Simulations Applied to Site Specific Mutagenesis and Ligand Binding: The Use of Free Energy Perturbation Methods
Kollman, P.
Kollman, P.
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Issue Date
1989
Submitted date
2023-11-03
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Adobe PDF, 5.08 MB
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Abstract
Wegive a brief review ofthe theoretical methodology andfree energy perturbation applications to proteins. We show that theoretical methods are capable of complementing experimental studies in leading to a clearer understanding ofthe effect of site specific mutations onligand binding, enzymecatalysis and protein stability.
Citation
Advances in protein design, 57 - 64
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Book chapter
conference paper
conference paper
Language
en
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Series/Report no.
GBF monographs ; Volume 12
ISSN
0930-4320
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ISBN
3527280243
0895739534
0895739534
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License
Attribution-NonCommercial-ShareAlike 4.0 International