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PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells.
Smida, Michal Cammann, Clemens Gurbiel, Slavyana Kerstin, Nadja Lingel, Holger Lindquist, Sabine Simeoni, Luca Brunner-Weinzierl, Monika C Suchanek, Miloslav Schraven, Burkhart
Smida, Michal
Cammann, Clemens
Gurbiel, Slavyana
Kerstin, Nadja
Lingel, Holger
Lindquist, Sabine
Simeoni, Luca
Brunner-Weinzierl, Monika C
Suchanek, Miloslav
Schraven, Burkhart
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Abstract
PAG/Cbp represents a ubiquitous mechanism for regulating Src family kinases by recruiting Csk to the plasma membrane, thereby controlling cellular activation. Since Src kinases are known oncogenes, we used RNA interference in primary human T cells to test whether the loss of PAG resulted in lymphocyte transformation.
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PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells. 2013, 11 (1):28 Cell Commun. Signal
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en
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1478-811X
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