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An unprecedented spiro [furan-2,1’-indene]-3-one derivative and other nematicidal and antimicrobial metabolites from Sanghuangporus sp. (Hymenochaetaceae, Basidiomycota) collected in Kenya
Chepkirui, Clara Cheng, Tian Matasyoh, Josphat Decock, Cony
Chepkirui, Clara
Cheng, Tian
Matasyoh, Josphat
Decock, Cony
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Abstract
Bioassay guided fractionation of extracts derived from submerged cultures of a Sanghuangporus sp. (i.e., the genus that was until recently referred to as the “Inonotus linteus complex” of medicinal mushrooms) originating from Kenya led to the isolation of a new spiro [furan-2,1’-indine]-3-one derivative, for which we propose the trivial name phelligridin L (1) together with the known compounds 3,14′-bihispidinyl (2), hispidin (3), ionylideneacetic acid (4), 1S-(2E)-5-[(1R)-2,2-dimethyl-6-methylidenecyclohexyl]-3-methylpent-2-enoic acid (5), phellidine E (6) and phellidine D (7). Compounds 1–3, showed moderate nematicidal activity against Caenorhabditis elegans with LD50 of 12.5 μg/m. The nematicidal activity of 3, 14′-bihispidinyl and hispidin (1, 2) has not been reported before. Furthermore, compounds 1–5 demonstrated moderate antimicrobial activity against various test organisms.
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