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Biosensors based on capacitance measurements and 2D-microelectrophoresis on lipid membranes
Sackmann, Erich Stelzle, Martin Weissmüller, G.
Sackmann, Erich
Stelzle, Martin
Weissmüller, G.
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Issue Date
1992
Submitted date
2024-04-17
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Adobe PDF, 4.88 MB
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Abstract
A great numberofbiological receptor moleculesare located within lipid bilayers. How can one use them for biosensor applications? Biological receptors should be reconstituted into their natural environment- e.g. the lipid bilayer - to achieve proper function. It is therefore necessary to develop (1) methodsfor the preparation of high resistance lipid/protein membranesonsolid supports and (2) appropriate transducers for the conversion of the chemicalto an electrical signal. In our case we apply capacitance measurement. Amplification of the sensor signal is a further important requirement for biosensors to achieve sufficient signal/noise ratios of the sensor. We suggestthe lateral 2D-microelectrophoresis. This could be a useful tool for the separation and local accumulation of different receptors.
Citation
Biosensors : fundamentals, technologies and applications, 133 - 143
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Type
Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 17
ISSN
0930-4320
EISSN
ISBN
3527284370
1560812206
1560812206
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Attribution-NonCommercial-ShareAlike 4.0 International