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Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model.
Mueller, Peter P Arnold, Sylvia Badar, Muhammad Bormann, Dirk Bach, Friedrich-Wilhelm Drynda, Andreas Meyer-Lindenberg, Andrea Hauser, Hansjörg Peuster, Matthias
Mueller, Peter P
Arnold, Sylvia
Badar, Muhammad
Bormann, Dirk
Bach, Friedrich-Wilhelm
Drynda, Andreas
Meyer-Lindenberg, Andrea
Hauser, Hansjörg
Peuster, Matthias
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2012-11
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Abstract
A small animal model was established to evaluate the potential of iron as a degradable implant material. After insertion into the tail of mice, the implants gradually degraded over a clinically relevant time period of several months. Histological analysis and gene expression data from whole-genome microarray analyses indicated a limited inflammatory reaction. No evidence of cellular responses to excess iron ions was detected, suggesting that the iron degradation products were metabolically inactive. Iron-rich compounds could be detected in the vicinity of the implant and in individual cells distant from the implantation site. These results demonstrate that the mouse model could be useful for the primary in vivo evaluation of novel implant materials and that iron degradation products can accumulate in diverse organs of the body.
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Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model. 2012, 100 (11):2881-9 J Biomed Mater Res A
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en
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1552-4965
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Archived with thanks to Journal of biomedical materials research. Part A