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New approaches to control infections: anti-biofilm strategies against gram-negative bacteria.

Sommer, Roman
; 
Joachim, Ines
; 
Wagner, Stefanie
; 
Titz, Alexander
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2013
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Abstract
Hospital-acquired bacterial infections, especially with Gram-negative pathogens, present a major threat due to the rapid spread of antibiotic-resistant strains. Targeting mechanisms of bacterial virulence has recently appeared as a promising new therapeutic paradigm. Biofilm formation is a bacterial lifestyle, which offers a survival advantage through its protective matrix against host immune defense and antibiotic treatment. Interfering with biogenesis of adhesive organelles, bacterial communication or carbohydrate-mediated adhesion as anti-biofilm strategies are reviewed.
Citation
New approaches to control infections: anti-biofilm strategies against gram-negative bacteria. 2013, 67 (4):286-90 Chimia (Aarau)
Affiliation
University of Konstanz, Department of Chemistry and Zukunftskolleg, Universitätsstrasse 10, D-78457 Konstanz.
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Journal
Chimia
URI
http://hdl.handle.net/10033/336700
DOI
PubMed ID
23967708
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Article
Language
en
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ISSN
0009-4293
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publications of the junior research group chemical biology of carbohydrates ([HIPS]CBCH)