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Clinical Course of Infection and Cross-Species Detection of Equine Parvovirus-Hepatitis.
Reinecke, Birthe Klöhn, Mara Brüggemann, Yannick Kinast, Volker Stang, Alexander Badenhorst, Marcha Koeppel, Katja Guthrie, Alan Groner, Ursula
Reinecke, Birthe
Klöhn, Mara
Brüggemann, Yannick
Kinast, Volker
Stang, Alexander
Badenhorst, Marcha
Koeppel, Katja
Guthrie, Alan
Groner, Ursula
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2021-07-26
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Abstract
The intriguing structural complexity of molecules produced by natural organisms is uncontested. Natural scaffolds serve as an important basis for the development of molecules with broad applications, e.g., therapeutics or agrochemicals. Research in recent decades has demonstrated that by means of classic metabolite extraction from microbes only a small portion of natural products can be accessed. The use of genome mining and heterologous expression approaches represents a promising way to discover new natural compounds. In this paper we report the discovery of a novel cyclic pentapeptide called bonsecamin through the heterologous expression of a cryptic NRPS gene cluster from Streptomyces albus ssp. chlorinus NRRL B-24108 in Streptomyces albus Del14. The new compound was successfully isolated and structurally characterized using NMR. The minimal set of genes required for bonsecamin production was determined through bioinformatic analysis and gene deletion experiments. A biosynthetic route leading to the production of bonsecamin is proposed in this paper.
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Viruses. 2021 Jul 26;13(8):1454. doi: 10.3390/v13081454.
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en
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1999-4915
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Attribution 4.0 International