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Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects.
Lindqvist, Richard Mundt, Filip Gilthorpe, Jonathan D Wölfel, Silke Gekara, Nelson O Kröger, Andrea Överby, Anna K
Lindqvist, Richard
Mundt, Filip
Gilthorpe, Jonathan D
Wölfel, Silke
Gekara, Nelson O
Kröger, Andrea
Överby, Anna K
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2016-10-24
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Abstract
Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined.
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Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects. 2016, 13 (1):277 J Neuroinflammation
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1742-2094