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Leader peptide exchange to produce hybrid, new-to-nature ribosomal natural products.

Franz, Laura
; 
Koehnke, Jesko
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Issue Date
2021-05-24
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Abstract
Ribosomal natural products contain exquisite post-translational peptide modifications that are installed by a range of pathway-specific enzymes. We present proof of principle for a Sortase A-based approach that enables peptide modification by enzymes from unrelated pathways. This allowed the one-pot synthesis of a new-to-nature, hybrid ribosomal natural product.
Citation
Chem Commun (Camb). 2021 Jun 2. doi: 10.1039/d0cc06889f. Epub ahead of print.
Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.
Publisher
RSC
Journal
Chemical communications (Cambridge, England)
URI
http://hdl.handle.net/10033/622912
DOI
10.1039/d0cc06889f
PubMed ID
34075907
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Article
Language
en
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ISSN
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1364-548X
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Attribution-NonCommercial 4.0 International
cbn
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publications of the research group structural biology of biosynthetic enzymes ([HIPS]SBBE)