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Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.
Kuhn, Maike Sühs, Kurt-Wolfram Akmatov, Manas K Klawonn, Frank Wang, Junxi Skripuletz, Thomas Kaever, Volkhard Stangel, Martin Pessler, Frank
Kuhn, Maike
Sühs, Kurt-Wolfram
Akmatov, Manas K
Klawonn, Frank
Wang, Junxi
Skripuletz, Thomas
Kaever, Volkhard
Stangel, Martin
Pessler, Frank
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2018-01-17
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Abstract
Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. We therefore applied a targeted metabolomics screen of CSF to three clinically distinct forms of VZV reactivation and infectious and non-infectious disease controls in order to identify biomarkers for CNS involvement in VZV reactivation.
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Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. 2018, 15 (1):20 J Neuroinflammation
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en
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1742-2094