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Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells.
Geis, Franziska K Galla, Melanie Hoffmann, Dirk Kuehle, Johannes Zychlinski, Daniela Maetzig, Tobias Schott, Juliane W Schwarzer, Adrian Goffinet, Christine Goff, Stephen P
Geis, Franziska K
Galla, Melanie
Hoffmann, Dirk
Kuehle, Johannes
Zychlinski, Daniela
Maetzig, Tobias
Schott, Juliane W
Schwarzer, Adrian
Goffinet, Christine
Goff, Stephen P
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2017-05-31
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Abstract
Retroviral vectors are derived from wild-type retroviruses, can be used to study retrovirus-host interactions and are effective tools in gene and cell therapy. However, numerous cell types are resistant or less permissive to retrovirus infection due to the presence of active defense mechanisms, or the absence of important cellular host co-factors. In contrast to multipotent stem cells, pluripotent stem cells (PSC) have potential to differentiate into all three germ layers. Much remains to be elucidated in the field of anti-viral immunity in stem cells, especially in PSC.
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Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. 2017, 14 (1):34 Retrovirology
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en
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1742-4690