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Bacterial Inclusion Bodies: Discovering Their Better Half.
Rinas, Ursula Garcia-Fruitós, Elena Corchero, José Luis Vázquez, Esther Seras-Franzoso, Joaquin Villaverde, Antonio
Rinas, Ursula
Garcia-Fruitós, Elena
Corchero, José Luis
Vázquez, Esther
Seras-Franzoso, Joaquin
Villaverde, Antonio
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Issue Date
2017-02-27
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Abstract
Bacterial inclusion bodies (IBs) are functional, non-toxic amyloids occurring in recombinant bacteria showing analogies with secretory granules of the mammalian endocrine system. The scientific interest in these mesoscale protein aggregates has been historically masked by their status as a hurdle in recombinant protein production. However, progressive understanding of how the cell handles the quality of recombinant polypeptides and the main features of their intriguing molecular organization has stimulated the interest in inclusion bodies and spurred their use in diverse technological fields. The engineering and tailoring of IBs as functional protein particles for materials science and biomedicine is a good example of how formerly undesired bacterial byproducts can be rediscovered as promising functional materials for a broad spectrum of applications.
Citation
Bacterial Inclusion Bodies: Discovering Their Better Half. 2017 Trends Biochem. Sci.
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en
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0968-0004