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Multi-Omics Approaches in Immunological Research.
Chu, Xiaojing Zhang, Bowen Koeken, Valerie A C M Gupta, Manoj Kumar Li, Yang
Chu, Xiaojing
Zhang, Bowen
Koeken, Valerie A C M
Gupta, Manoj Kumar
Li, Yang
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2021-06-11
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Abstract
The immune system plays a vital role in health and disease, and is regulated through a complex interactive network of many different immune cells and mediators. To understand the complexity of the immune system, we propose to apply a multi-omics approach in immunological research. This review provides a complete overview of available methodological approaches for the different omics data layers relevant for immunological research, including genetics, epigenetics, transcriptomics, proteomics, metabolomics, and cellomics. Thereafter, we describe the various methods for data analysis as well as how to integrate different layers of omics data. Finally, we discuss the possible applications of multi-omics studies and opportunities they provide for understanding the complex regulatory networks as well as immune variation in various immune-related diseases.
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Front Immunol. 2021 Jun 11;12:668045. doi: 10.3389/fimmu.2021.668045.
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en
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1664-3224
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Attribution 4.0 International