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Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.

Steinbach, Anke
; 
Maurer, Christine K
; 
Weidel, Elisabeth
; 
Henn, Claudia
; 
Brengel, Christian
; 
Hartmann, Rolf W
; 
Negri, Matthias
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2013
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Abstract
PQS (PseudomonasQuinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that induces virulence factor production and biofilm formation. The enzyme PqsD catalyses the biosynthesis of HHQ.
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Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies. 2013, 6 (1):10 BMC Biophys
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BMC biophysics
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http://hdl.handle.net/10033/311421
DOI
10.1186/2046-1682-6-10
PubMed ID
23916145
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Article
Language
en
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2046-1682
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publications of the research group drug design and optimization(HIPS]DDOP)