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Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner.

Nedelko, Tatiana
; 
Kollmus, Heike
; 
Klawonn, Frank
; 
Spijker, Sabine
; 
Lu, Lu
; 
Heßman, Manuela
; 
Alberts, Rudi
; 
Williams, Robert W
; 
Schughart, Klaus
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2012
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Abstract
There is strong but mostly circumstantial evidence that genetic factors modulate the severity of influenza infection in humans. Using genetically diverse but fully inbred strains of mice it has been shown that host sequence variants have a strong influence on the severity of influenza A disease progression. In particular, C57BL/6J, the most widely used mouse strain in biomedical research, is comparatively resistant. In contrast, DBA/2J is highly susceptible.
Citation
Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. 2012, 13:411 BMC Genomics
Affiliation
Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, 38124, Braunschweig, Germany.
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BMC genomics
URI
http://hdl.handle.net/10033/278939
DOI
10.1186/1471-2164-13-411
PubMed ID
22905720
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Article
Language
en
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1471-2164
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publications of the research group infection genetics (INFG)