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Nuclear lncRNA stabilization in the host response to bacterial infection.

Munschauer, Mathias
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2018-07-02
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Abstract
Long non-coding RNAs (lncRNAs) play important roles in many cellular pathways, but their contribution to the defense of eukaryotic cells against pathogens remains poorly understood. A new study from Imamura et al in The EMBO Journal reports that Salmonella infection in human cells impacts nuclear RNA decay, which in turn drives the accumulation of otherwise unstable nuclear lncRNAs, some of which may have protective effects against this common bacterial pathogen. These unexpected findings demand more efforts to fully decrypt the molecular functions of lncRNAs in innate and adaptive immunity.
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Affiliation
HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.
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URI
http://hdl.handle.net/10033/621572
DOI
10.15252/embj.201899875
PubMed ID
29934294
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1460-2075
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Attribution-NonCommercial-ShareAlike 3.0 United States
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publications of the department of RNA biology of bacterial infections([HIRI] RABI)