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Autophagy-A Story of Bacteria Interfering with the Host Cell Degradation Machinery.
Riebisch, Anna K Mühlen, Sabrina Beer, Yan Yan Schmitz, Ingo
Riebisch, Anna K
Mühlen, Sabrina
Beer, Yan Yan
Schmitz, Ingo
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2021-01-22
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Abstract
Autophagy is a highly conserved and fundamental cellular process to maintain cellular homeostasis through recycling of defective organelles or proteins. In a response to intracellular pathogens, autophagy further acts as an innate immune response mechanism to eliminate pathogens. This review will discuss recent findings on autophagy as a reaction to intracellular pathogens, such as Salmonella typhimurium, Listeria monocytogenes, Mycobacterium tuberculosis, Staphylococcus aureus, and pathogenic Escherichia coli. Interestingly, while some of these bacteria have developed methods to use autophagy for their own benefit within the cell, others have developed fascinating mechanisms to evade recognition, to subvert the autophagic pathway, or to escape from autophagy.
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Pathogens. 2021 Jan 22;10(2):110. doi: 10.3390/pathogens10020110.
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Review
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en
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2076-0817
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Attribution 4.0 International