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Archazolid and apicularen: novel specific V-ATPase inhibitors.
Huss, Markus Sasse, Florenz Kunze, Brigitte Jansen, Rolf Steinmetz, Heinrich Ingenhorst, Gudrun Zeeck, Axel Wieczorek, Helmut
Huss, Markus
Sasse, Florenz
Kunze, Brigitte
Jansen, Rolf
Steinmetz, Heinrich
Ingenhorst, Gudrun
Zeeck, Axel
Wieczorek, Helmut
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Issue Date
2005-08-04
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Abstract
V-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their localization in a multitude of eukaryotic membranes, they energize many different transport processes. Since their malfunction is correlated with various diseases in humans, the elucidation of the properties of this enzyme for the development of selective inhibitors and drugs is one of the challenges in V-ATPase research.
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Archazolid and apicularen: novel specific V-ATPase inhibitors. 2005, 6:13 BMC Biochem.
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en
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1471-2091