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PEG-NAD* IN AMPEROMETRIC DEHYDROGENASE ELECTRODES WITH COENZYME RECYCLING
Lammert, R. Ogbomo, I. Baumeister, T. Danzer, J. Kittsteiner-Eberle, R. Schmidt, H.-L.
Lammert, R.
Ogbomo, I.
Baumeister, T.
Danzer, J.
Kittsteiner-Eberle, R.
Schmidt, H.-L.
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Issue Date
1989
Submitted date
2023-12-06
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Abstract
A new method for the synthesis of PEG-NAD* via activation of PEG with carbonyldiimidazole is described; a very stable non-dialysable and biologically active coenzyme derivative is obtained. In compact amperometric dehydrogenase electrodes this coenzyme derivative, physically entrapped with the dehydrogenase and placed in proximity to a modified graphite electrode surface, leads to enzyme deactivation and extraction of the catalyst. Therefore electrodes with low response and short lifetime result. In addition the response of these electrodes is dominated by the very high diffusion coefficient and the high viscosity of its solution. Possibilities to overcome these problems are discussed.
Citation
Biosensors : applications in medicine, environmental protection and process control, 93 - 98
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Type
Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 13
ISSN
0930-4320
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ISBN
3527280324
0895739550
0895739550
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Attribution-NonCommercial-ShareAlike 4.0 International