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Monochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera.

Chepkirui, Clara
; 
Richter, Christian
; 
Matasyoh, Josphat Clement
; 
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2016-12
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Abstract
Eight previously undescribed compounds were isolated and characterised from the supernatant and mycelium of a culture of the basidiomycete Favolaschia calocera originating from Kakamega equatorial rainforest in Kenya. These were: 9- oxostrobilurins A, G, K and I and the four monochlorinated calocerins A, B, C and D. The calocerins extend our knowledge of halogenated compounds obtained from natural sources. Four further known compounds were also identified: strobilurin G, favolon, pterulinic acid and 2,3 -dihydro-1-benzoxepin derivative. The four oxostrobilurins exhibited prominent antifungal and cytotoxic activities while the four calocerins only showed cytotoxic activity.
Citation
Monochlorinated calocerins A-D and 9-oxostrobilurin derivatives from the basidiomycete Favolaschia calocera. 2016, 132:95-101 Phytochemistry
Affiliation
Helmholtz Centre for infection research, Ihoffenstr. 7, 38124 Braunschweig, Germany.
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Journal
Phytochemistry
URI
http://hdl.handle.net/10033/620851
DOI
10.1016/j.phytochem.2016.10.001
PubMed ID
27745908
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Article
Language
en
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ISSN
1873-3700
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publications of the research group of microbial drugs (MWIS)